BPmax | log10(BPmax) | Imax | ||
---|---|---|---|---|
mean ± S.E.M. | ||||
Heroin | ||||
IRR 25 | Cocaine alone | 350 ± 50 | 2.53 ± 0.08 | 18.0 ± 1.7 |
+0.001 | 350 ± 50 | 2.53 ± 0.08 | 18.8 ± 1.3 | |
+0.01 | 300 ± 58 | 2.45 ± 0.09 | 17.8 ± 1.3 | |
IRR 100 | Cocaine alone | 1000 ± 346 | 3.00 ± 0.17 | 14.5 ± 1.4 |
+0.001 | 900 ± 252 | 2.90 ± 0.12 | 14.3 ± 0.9 | |
+0.01 | 900 ± 252 | 2.90 ± 0.12 | 12.8 ± 1.6 | |
IRR 400 | Cocaine alone | 1600 ± 0.0 | 3.20 ± 0.00* | 11.5 ± 0.3* |
+0.001 | 2400 ± 462 | 3.35 ± 0.09 | 12 ± 0.7 | |
+0.01 | 2400 ± 462 | 3.35 ± 0.09 | 12.8 ± 1.1 | |
Alfentanil | ||||
IRR 25 | Cocaine alone | 250 ± 50 | 2.38 ± 0.08 | 15.8 ± 0.5 |
+0.0001 | 350 ± 50 | 2.53 ± 0.08 | 17.3 ± 1.0 | |
+0.001 | 400 ± 0 | 2.60 ± 0.00 | 17.8 ± 0.8 | |
IRR 400 | Cocaine alone | 1400 ± 600 | 3.05 ± 0.15* | 9.0 ± 2.0* |
+0.0001 | 1800 ± 503 | 3.20 ± 0.12 | 10.3 ± 1.0 | |
+0.001 | 2400 ± 462 | 3.35 ± 0.09 | 11.5 ± 0.6 | |
Nalbuphine | ||||
IRR 25 | Cocaine alone | 250 ± 50 | 2.38 ± 0.08 | 15.8 ± 0.5 |
+0.001 | 200 ± 0 | 2.30 ± 0.00 | 14.5 ± 0.3 | |
+0.01 | 200 ± 0 | 2.30 ± 0.00 | 14.8 ± 0.5 | |
IRR 400 | Cocaine alone | 1400 ± 600 | 3.05 ± 0.15* | 9.0 ± 2.0* |
+0.001 | 1600 ± 566 | 3.13 ± 0.14 | 10.0 ± 2.4 | |
| +0.01 | 1600 ± 566 | 3.13 ± 0.14 | 10.0 ± 1.5 |
↵* p < 0.05 vs. cocaine alone at IRR 25, Bonferroni t test.