Rapid and time-dependent inhibition of COX-2 by valdecoxib
Ki | Kinact | Kobserved | |
|---|---|---|---|
| μM | s | M/s | |
| Valdecoxib | 35 | 3.8 | 110,000 |
| Celecoxib | 3 | 0.4 | 130,000 |
| 3.5 | 0.2 | 57,000 | |
| Rofecoxib | NM | NM | 7000 |
| 29 | 0.04 | 1300 | |
| Etoricoxib | NM | NM | 850 |
|
|
430
|
0.06
|
130
|
Italics, N,N,N′,N′-tetramethyl-p-phenylene diamine assay; NM, not measurable.