Dose of Drug(s) | Startle Amplitude | ||
---|---|---|---|
Startle Pulse Alone | Prepulse + Startle Pulse | ||
mg/kg | Arbitrary units | ||
Xanomeline | |||
Vehicle/vehicle | 209 + 36 | 71 + 18 | |
Vehicle/apomorphine | 229 + 40 | 139 + 29 | |
3.0/apomorphine | 297 + 52 | 158 + 18 | |
10/apomorphine | 268 + 68 | 146 + 59 | |
30/apomorphine | 156 + 21 | 64 + 14 | |
BuTAC | |||
Vehicle/vehicle | 176 + 22 | 50 + 7 | |
Vehicle/apomorphine | 283 + 70 | 164 + 42 | |
0.01/apomorphine | 178 + 19 | 108 + 14 | |
0.03/apomorphine | 141 + 35 | 77 + 22 | |
0.1/apomorophine | 158 + 23 | 57 + 9 | |
Oxotremorine | |||
Vehicle/vehicle | 142 + 21 | 40 + 11 | |
Vehicle/apomorphine | 244 + 63 | 143 + 35 | |
0.03/apomorphine | 205 + 49 | 151 + 42 | |
0.1/apomorphine | 197 + 33 | 130 + 23 | |
0.3/apomorphine | 96 + 14 | 40 + 8 | |
RS86 | |||
Vehicle/vehicle | 145 + 17 | 38 + 7 | |
Vehicle/apomorphine | 260 + 54 | 151 + 34 | |
0.3/apomorphine | 178 + 23 | 99 + 14 | |
1.0/apomorphine | 190 + 40 | 70 + 16 | |
3.0/apomorphine | 198 + 40 | 92 + 24 | |
Pilocarpine | |||
Vehicle/vehicle | 230 + 37 | 42 + 10 | |
Vehicle/apomorphine | 170 + 29 | 74 + 14 | |
3.0/apomorphine | 119 + 30a | 38 + 7 | |
10/apomorphine | 115 + 13a | 32 + 2 | |
30/apomorphine | 65 + 15a | 34 + 8 | |
Milameline | |||
Vehicle/vehicle | 188 + 39 | 51 + 10 | |
Vehicle/apomorphine | 151 + 21 | 77 + 12 | |
0.3/apomorphine | 172 + 33 | 95 + 17 | |
1.0/apomorphine | 299 + 96 | 177 + 60 | |
3.0/apomorphine | 169 + 27 | 70 + 11 | |
Sabcomeline | |||
Vehicle/vehicle | 292 + 40 | 66 + 10 | |
Vehicle/apomorphine | 207 + 39 | 104 + 17 | |
0.3/apomorphine | 344 + 61 | 205 + 48 | |
1.0/apomorphine | 228 + 37 | 104 + 22 | |
3.0/apomorphine | 198 + 14 | 83 + 14 | |
Agonists alone | |||
Vehicle | 199 + 27 | 57 + 21 | |
Xanomeline (30 mg/kg) | 52 + 12a | 16 + 2 | |
BuTAC (0.1 mg/kg) | 91 + 17a | 34 + 8 | |
RS86 (3.0 mg/kg) | 50 + 8a | 19 + 2 | |
Oxotremorine (0.3 mg/kg) | 51 + 7a | 18 + 3 |
↵ a P < 0.05 versus vehicle or vehicle/vehicle group by Dunnett's test.