Parameters of the inhibition of [3H]8-OH-DPAT binding by 0.63 mg/kg F 13640 administered i.p.
Brain Region | max | tmax | t1/2 max | t1/2 asym |
|---|---|---|---|---|
| % of control | min | |||
| Hippocampus | 70.5 ± 5.8 | 30.3 ± 9.8 | 5.6 ± 2.2 | 263.8 ± 81.7 |
| Entorhinal cortex | 61.2 ± 5.7 | 32.1 ± 10.1 | 5.4 ± 2.1 | 514.5 ± 255.6 |
| Frontal cortex | 60.7 ± 11.4 | 15.4 ± 6.3 | 2.6 ± 1.4 | 211.9 ± 59.0 |
|
| N.S. | N.S. | N.S. | N.S. |
N.S., no significant difference between the different brain regions examined (i.e., p > 0.05).