TABLE 1

Effect of rosolic acid and its derivatives on endothelial heme oxygenase activity and cell viability The table shows the activity of heme oxygenase measured 6 h after exposure of endothelial cells to 15 μM RA, aurintricarboxylic acid, or pararosaniline chloride. Cell viability was also measured after incubation of the triphenylmethanes for 6 h, and no significant cytotoxicity was observed. Data are expressed as the mean ± S.E.M. of five independent experiments.

Heme Oxygenase Activity Cell Viability
pmol bilirubin/mg protein/h % of control
Control (6 h) 453 ± 43 100 ± 2.9
Rosolic acid (6 h) 2676 ± 117* 94 ± 1.7
Aurintricarboxylic acid (6 h) 332 ± 70 98 ± 2.3
Pararosaniline chloride (6 h) 375 ± 64 96 ± 3.1
  • * p < 0.05 vs. control