TABLE 3

Effects of quinelorane (0.0–0.32 mg/kg i.p.) on acoustic startle amplitude after pretreatment with either SCH39166 or eticlopride (1.0 mg/kg i.p.) in outbred Sprague-Dawley rats and inbred DBA/2J mice Mouse, n = 16 female and male; rat, n = 8 female and male. Values (arbitrary units) represent mean ± S.E.M. startle magnitude.

Sprague-Dawley Rat DBA/2J Mice
Vehicle + quinelorane (mg/kg) Female Male
   0.0 + 0.0 537.0 ± 92.9 84.3 ± 10.2 96.4 ± 17.7
   0.0 + 0.01 265.4 ± 73.7** 87.4 ± 15.6 82.5 ± 15.6
   0.0 + 0.032 159.0 ± 29.5** 70.2 ± 23.0 42.1 ± 11.7**
   0.0 + 0.1 123.3 ± 24.0** 32.8 ± 9.9** 23.7 ± 7.8**
SCH39166 + quinelorane (mg/kg)
   1.0 + 0.0 608.5 ± 132.7 44.6 ± 7.6†
   1.0 + 0.032 368.0 ± 58.3 48.5 ± 8.4
   1.0 + 0.1 266.7 ± 71.7* 20.8 ± 5.0
   1.0 + 0.32 244.9 ± 47.3* 17.8 ± 2.5
Eticlopride + quinelorane (mg/kg)
   1.0 + 0.0 613.5 ± 116.5 70.1 ± 17.5
   1.0 + 0.032 563.3 ± 110.4 45.6 ± 14.5*
   1.0 + 0.1 515.4 ± 67.2 51.5 ± 14.5*
   1.0 + 0.32 377.6 ± 71.0* 38.4 ± 6.1*

  • ↵* P < 0.05 compared with antagonist + agonist vehicle

  • ↵** P < 0.01 compared with antagonist + agonist vehicle

  • ↵† P < 0.05 compared with vehicle + agonist vehicle