Dose | Time on Rotorod | |
---|---|---|
Baseline | Test | |
mg/kg | s | |
Duloxetine i.p. | ||
0 | 120 ± 0 | 112 ± 8 |
1.0 | 120 ± 0 | 120 ± 0 |
3.0 | 120 ± 0 | 120 ± 0 |
10 | 120 ± 0 | 107 ± 9 |
30 | 120 ± 0 | 101 ± 12 |
Duloxetine p.o. | ||
0 | 120 ± 0 | 120 ± 0 |
1.0 | 120 ± 0 | 120 ± 0 |
3.0 | 120 ± 0 | 120 ± 0 |
10 | 120 ± 0 | 120 ± 0 |
30 | 120 ± 0 | 115 ± 5 |
Morphine s.c. | ||
0 | 120 ± 0 | 120 ± 0 |
1.0 | 120 ± 0 | 115 ± 5 |
3.0 | 120 ± 0 | 102 ± 12 |
10 | 120 ± 0 | 70 ± 13a |
30 | 120 ± 0 | 80 ± 17 |
Ibuprofen p.o. | ||
0 | 120 ± 0 | 120 ± 0 |
30 | 120 ± 0 | 120 ± 0 |
100 | 120 ± 0 | 120 ± 0 |
300 | 120 ± 0 | 120 ± 0 |
1000 | 120 ± 0 | 85 ± 16a |
Gabapentin p.o. | ||
3 | 120 ± 0 | 120 ± 0 |
10 | 120 ± 0 | 120 ± 0 |
30 | 120 ± 0 | 120 ± 0 |
100 | 120 ± 0 | 120 ± 0 |
↵ a p < 0.05 vs. 0 mg/kg, Dunnett's t test