TABLE 1

Lack of effects of duloxetine on motor performance as measured on the Rotorod Mice were administered the indicated dose of duloxetine i.p. or p.o., morphine s.c., ibuprofen p.o., or gabapentin p.o., then tested on the Rotorod for 30 min (following i.p. or s.c. administration) or 60 min (following p.o. administration) later. Each value represents the mean ± S.E.M. of 10 mice.

Dose Time on Rotorod
Baseline Test
mg/kg s
Duloxetine i.p.
   0 120 ± 0 112 ± 8
   1.0 120 ± 0 120 ± 0
   3.0 120 ± 0 120 ± 0
   10 120 ± 0 107 ± 9
   30 120 ± 0 101 ± 12
Duloxetine p.o.
   0 120 ± 0 120 ± 0
   1.0 120 ± 0 120 ± 0
   3.0 120 ± 0 120 ± 0
   10 120 ± 0 120 ± 0
   30 120 ± 0 115 ± 5
Morphine s.c.
   0 120 ± 0 120 ± 0
   1.0 120 ± 0 115 ± 5
   3.0 120 ± 0 102 ± 12
   10 120 ± 0 70 ± 13a
   30 120 ± 0 80 ± 17
Ibuprofen p.o.
   0 120 ± 0 120 ± 0
   30 120 ± 0 120 ± 0
   100 120 ± 0 120 ± 0
   300 120 ± 0 120 ± 0
   1000 120 ± 0 85 ± 16a
Gabapentin p.o.
   3 120 ± 0 120 ± 0
   10 120 ± 0 120 ± 0
   30 120 ± 0 120 ± 0
   100 120 ± 0 120 ± 0
  • a p < 0.05 vs. 0 mg/kg, Dunnett's t test