TABLE 1

Brain and plasma concentrations of BMS-299897 in Tg2576 mice treated for 1 or 14 days Samples were collected 3 h after the final 100-mg/kg dose. Each group consisted of 10 to 11 mice 5 or 17 months of age and were the same mice as shown in Fig. 8. Concentration of BMS-299897 was actually measured in picomoles per gram, but the assumption was made that 1 g of tissue was equal to 1 ml to allow a better comparison with plasma data.