Decreased pentobarbital clearance in homozygous Cprlow mice
Adult male mice received pentobarbital (10 mg/ml in phosphate-buffered saline) i.p. at a dose of 60 mg/kg. The lengths of time between drug administration and the loss and the subsequent recovery of righting reflex were recorded. Values presented are means ± S.E.M.
Strain | Onset of Sleep | Sleep Duration | |
|---|---|---|---|
| min | |||
| B6 (n = 4) | 4.5 ± 0.9 | 50 ± 6 | |
| 129/Sv (n = 5) | 6.4 ± 2.0 | 65 ± 10 | |
| Cprlow/low (n = 5) | 4.5 ± 1.4 | 203 ± 23a | |
↵ a Significantly different from the two control groups; P < 0.01.