Plasma concentrations of free UK-357,903 and free enalaprilat
Values are geometric means with 95% confidence interval (in parentheses) for data from individual animals for UK-357,903 (n = 5-8) and for pooled samples from two or three animals for enalaprilat (n = 3 pooled samples).
Treatment | UK-357,903 | Enalaprilat | ||||
|---|---|---|---|---|---|---|
| UK-357,903 | UK-357,903 + Enalapril | Enalapril | UK-357,903 + Enalapril | |||
| nM | nM | |||||
| Day 1 | 10.1 | 8.4 | 9.8 | 9.3 | ||
| (7.3, 14.2) | (6.6, 10.6) | (5.8, 16.6) | (2.8, 30.7) | |||
| Day 2 | 8.1 | 10.9 | 15.1 | 15.8 | ||
| (6.3, 10.4) | (7.9, 15.0) | (8.7, 26.3) | (12.3, 20.2) | |||
| Day 3 | 7.6 | 7.5 | 15.2 | 15.7 | ||
| (6.1, 9.4) | (5.5, 10.4) | (4.5, 53.1) | (5.4, 45.8) | |||
| Day 4 | 7.1 | 6.6 | 15.0 | 20.1 | ||
|
| (5.4, 9.3) | (4.9, 8.8) | (6.6, 34.2) | (8.7, 46.5) | ||