Therapeutic Drug | Tmax | t1/2 | Vdss/F | Cl/F | |
---|---|---|---|---|---|
min | l/kg | l/min/kg | |||
Acyclovir | 52 (±29.5) | 227.6 (±112.9) | 10.6 (±2.1) | 2.5 (±1.19) (×10-2) | |
Acyclovir/PI | 28.3 (±7.6) | 388.4 (±92.0) | 6.1 (±2.1) | 1.0 (±0.6) (×10-2) | |
Acyclovir/ΔG/PI | 20 (±10.0) | 254.4 (±115.8) | 8.0 (±2.1) | 2.8 (±1.4) (×10-2) | |
Ritonavir | 340 (±91.7) | N/A | N/A | N/A | |
Ritonavir/PI | 390 (±42.3) | N/A | N/A | N/A | |
Ritonavir/ΔG/PI | 140 (±91.7)*, ** | 522.9 (±29.7) | 1.4 (±0.2) | 1.9 (±0.1) (×10-3) | |
Saquinavir | 13.3 (±5.8) | 473.6 (±107.6) | 32.5 (±5.5) | 7.0 (±2.2) (×10-2) | |
Saquinavir/PI | 30 (±0.0)* | 584.1 (±148.2) | 20.5 (±5.2) | 5.2 (±1.6) (×10-2) | |
Saquinavir/ΔG/PI | 10 (±0.0)** | 195.7 (±86.5)* | 25.8 (±4.6) | 10.1 (±3.4) (×10-2) | |
Cyclosporin A | 20 (±9.5) | 826.8 (±242.3) | 97.7 (±49.4) | 0.6 (±0.5) | |
Cyclosporin A/PI | 20 (±0.0) | 519.2 (±180.3) | 71.5 (±31.3) | 0.1 (±0.0) | |
Cyclosporin A/ΔG/PI | 16.7 (±5.8) | 446.1 (±155.6) | 1.3 (±0.1)*, ** | 1.6 (±0.3) (×10-3)*, ** |