TABLE 1

Effect of rapamycin on Ca²⁺ sensitivity of isometric force

Isometric force is expressed as a ratio normalized to the prerapamycin control force for each individual muscle type.

	Normalized F_o: Rapamycin	Hill Coefficient (n_H)^a			pCa₅₀^a		ΔpCa₅₀
	Normalized F_o: Rapamycin		Control	Rapamycin	Control	Rapamycin	ΔpCa₅₀
Rabbit skeletal (1 μM)	0.89 ± 0.04	2.77 ± 0.47	3.91 ± 0.58^b	5.77 ± 0.01	5.90 ± 0.02^b	0.13
Rabbit cardiac (1 μM)	0.97 ± 0.02	3.69 ± 0.29	3.05 ± 0.18^b	5.55 ± 0.02	5.63 ± 0.01^b	0.08
Rat cardiac (100 μM)	0.99 ± 0.07	3.76 ± 0.84	3.36 ± 0.59	5.40 ± 0.04	5.51 ± 0.05^b	0.11

↵ a Values (mean ± S.E.M.; n = 6 for rabbit skeletal and cardiac, n = 8 for rat cardiac) obtained from Hill fits to data from individual muscle preparations.
↵ b Significance expressed as P < 0.05 when compared with 0 μM rapamycin.