Paclitaxel 6α-Hydroxylation Rate (Percent of Control) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
NADPH | NADPH + Glutathione (2 mM) | NADPH + Superoxide Dismutase (1000 U/ml) | NADPH + Mannitol (1 mM) | NADPH + Torsemide (500 μM) | NADPH + Ultrafiltration | ||||||
Control | 100 | 100 | 100 | 100 | 100 | 100 | |||||
Nortriptyline (200 μM) | 67.1 | 67.4 | 65.4 | 61.4 | 106.7 | 56.6 | |||||
Verapamil (100 μM) | 44.4 | 42.7 | 49.2 | 45.5 | 98.5 | 34.7 | |||||
Fluoxetine (200 μM) | 46.4 | 53.9 | 46.4 | 48.5 | 101.7 | 41.3 | |||||
Amiodarone (4 μM) | 38.8 | 33.1 | 37.4 | 38.7 | 108.4 | 29.0 | |||||
Isoniazid (500 μM) | 70.4 | 67.8 | 68.5 | 67.7 | 91.3 | 108.4 | |||||
Phenelzine (4 μM) | 14.1 | 77.1 | 93.3 | 13.2 | 94.3 | 53.6 |