TABLE 1

Mucosal concentration of sodium channel blockers required to inhibit 50% of short-circuit current by HBE and OBE cells

Values represent mean ± S.E.M.; n equals the number of observations. The IC50 value was calculated fitted to a nonlinear regression sigmoidal dose-response curve with no weighting.




Amiloride

Benzamil

Phenamil
Human
    IC50 (nM) 284 ± 31 36 ± 4 75 ± 8
    n 15 15 11
Ovine
    IC50 (nM) 608 ± 116 46 ± 7 116 ± 30
    n
6
7
4