Study protocol
Treatment | Length of Treatment | |
|---|---|---|
| Group | ||
| 1 (8)a | No treatment (naive) | |
| 2 (12) | FCA alone (RA) | |
| 3 (8) | FCA, ASA 30 mg/kg/day | From day 7 to day 21 |
| 4 (8) | FCA, naproxen 10 mg/kg/day | From day 7 to day 21 |
| 5 (8) | FCA, HCT-3012 15 mg/kg/day | From day 7 to day 21 |
| 6 (8) | FCA, celecoxib 30 mg/kg/day | From day 7 to day 21 |
| 7 (8) | FCA, ASA + naproxen | From day 7 to day 21 |
| 8 (8) | FCA, ASA + HCT-3012 | From day 7 to day 21 |
|
9 (8) |
FCA, ASA + celecoxib |
From day 7 to day 21 |
↵ a Number of rats are indicated in parentheses.