ECF pharmacokinetic parameter estimates after intravenous administration of 10 mg kg-1 MCPA or 2′-dCPA Presented are both the population mean estimates (with intersubject variability between brackets) and the mean of the individual post hoc Bayesian estimates. p < 0.05.
MCPA | 2′-dCPA | |
|---|---|---|
| Q14 (μl min-1) | ||
| Population mean | 1.94 ± 0.37 (39%) | 1.64 ± 0.48 (27%) |
| Mean of post hoc Bayesian estimates | 2.06 ± 0.73 | 1.62 ± 0.44 |
| Q14,u (μl min-1) | ||
| Population mean | 6.24 ± 2.78 | 4.29 ± 1.29 |
| Q45 (μl min-1) | ||
| Population mean | 0.342 ± 0.05 | 0.0631 ± 0.018 |
| Mean of post hoc Bayesian estimates | 0.342 | |
| Q46 (μl min-1) | ||
| Population mean | 0.167 ± 0.04 | 0.279 ± 0.10 |
| V4 (ml) | ||
| Population mean | 4.91 ± 1.61 (72%) | 0.278 ± 0.080 |
| Mean of post hoc Bayesian estimates | 6.55 ± 4.7 | |
| V5 (ml) | ||
| Population mean | 280 ± 67 | 181 ± 39 |
| V6 (ml) | ||
| Population mean | 4.91 ± 1.61 (72%) | 0.278 ± 0.080 |
| Mean of post hoc Bayesian estimates | 6.55 ± 4.7 | |
|
n
| 9 | 7 |