TABLE 1

Variants in promoter region of the MDR1 gene in Japanese (n = 94) and Caucasian (n = 96) subjects

Location	Position	Allele	Nucleotide Sequence	Allele Frequency			Genotype	Frequency
Location	Position	Allele	Nucleotide Sequence				Genotype		Japanese	Caucasian		Japanese	Caucasian
Promoter	-1517a^a	T^b	agggTttaa	0.920	1.000	T/T	0.840	1.000
				(0.881-0.959)^c		T/C	0.160	0.000
		C	agggCttaa	0.080	0.000	C/C	0.000	0.000
				(0.041-0.119)
	-1459a^a	G^b	gtgaGataa	0.750	1.000	G/G	0.553	1.000
				(0.688-0.812)		G/A	0.394	0.000
		A	gtgaAataa	0.250	0.000	A/A	0.053	0.000
				(0.188-0.312)
	-1423a^a	GA^b	cagaGAtcat	1.000	0.995	GA/GA	1.000	0.990
				(0.985-1.005)		GA/-	0.000	0.010
		Deletion	caga_tcat	0.000	0.005	-/-	0.000	0.000
					(-0.027-0.015)
	-1132a^a	CCATC^b	aagaCCATCctgg	0.963	1.000	CCATC/CCATC	0.926	1.000
				(0.936-0.990)		CCATC/-	0.074	0.000
		Deletion	aaga_ctgg	0.037	0.000	-/-	0.000	0.000
				(0.01-0.064)
	-1017a^a	T^b	atggTgtga	0.920	0.984	T/T	0.840	0.969
				(0.881-0.959)	(0.966-1.002)	T/C	0.160	0.031
		C	atggCgtga	0.08	0.016	C/C	0.000	0.000
				(0.041-0.119)	(-0.002-0.034)
	-824a^a	T^b	attaTggct	0.995	1.000	T/T	0.989	1.000
					(0.985-1.005)	T/C	0.011	0.000
		C	attaCggct	0.005	0.000	C/C	0.000	0.000
				(-0.027-0.015)
	-755a^a	A^b	agtgAtttt	1.000	0.995	A/A	1.000	0.990
				(0.985-1.005)		A/G	0.000	0.010
		G	agtgGtttt	0.000	0.005	G/G	0.000	0.000
					(-0.027-0.015)
	-41a^a	A^b	cccaAtgat	0.894	1.000	A/A	0.798	1.000
				(0.850-0.938)		A/G	0.191	0.000
		G	cccaGtgat	0.106	0.000	G/G	0.011	0.000
				(0.062-0.150)
	-145²	C^b	gaagCctga	0.968	1.000	C/C	0.936	1.000
				(0.943-0.993)		C/G	0.064	0.000
		G	gaagGctga	0.032	0.000	G/G	0.000	0.000
				(0.007-0.057)
Exon 1	-129²	T^b	cgagTagcg	0.920	0.984	T/T	0.840	0.969
				(0.881-0.959)	(0.966-1.002)	T/C	0.160	0.031
		C	cgagCagcg	0.080	0.016	C/C	0.000	0.000
				(0.041-0.119)	(-0.002-0.034)

^d Position is relative to the initiation site of translation, which is defined as +1.
↵ a Position is relative to the initiation site of exon 1a, which is defined as +1a
↵ b Reference sequence GenBank accession no. AC002457
↵ c The 95% confidence intervals are given in parentheses