Mean estimated model parameters following a 60-min intravenous infusion of exendin-4 in healthy and type 2 diabetic subjects under hyperglycemic clamp conditions
Healthy Subjects | Type 2 Diabetic Subjects | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter (Units) | Prior | Mean | CV% | Prior | Mean | CV% | ||||
| Tdur (min) | 1.9 | 1.71 | 7.1 | 1.9 | 1.76 | 7.3 | ||||
| Tsec (min) | 3.5 | 3.41 | 8.6 | 3.5 | 3.54 | 20 | ||||
| Irel (μU/ml) | NI | 49.9 | 85 | NI | 13.0a | 199 | ||||
| V (dl/kg) | 1.3 | 1.39 | 20 | 1.3 | 1.42 | 14 | ||||
| p1 (min−1) | 3.0 × 10−2 | 2.28 × 10−2 | 20 | 1.3 × 10−2 | 2.09 × 10−2 | 35 | ||||
| p2 (min−1) | 3.0 × 10−2 | 3.39 × 10−2 | 57 | 1.3 × 10−2 | 1.61 × 10−2a | 47 | ||||
| p3 (min−2/μU/ml) | 7.50 × 10−6 | 5.60 × 10−6 | 52 | 3.0 × 10−6 | 1.49 × 10−6† | 72 | ||||
| γ (μU ml−1min−2/mg dl−1) | 2.8 × 10−4 | 5.52 × 10−4 | 43 | 3.0 × 10−4 | 2.43 × 10−4* | 76 | ||||
| h (mg/dl) | 98 | 63.2 | 28 | 137 | 144† | 40 | ||||
| n (min−1) | 0.21 | 0.165 | 41 | 0.13 | 0.204 | 26 | ||||
| Emax (μU ml−1min−2/mg dl−1) | NI | 2.81 × 10−3 | 55 | NI | 1.54 × 10−3a | 86 | ||||
| EA50 (pmol/kg) | NI | 0.268 | 64 | NI | 0.111a | 69 | ||||
| ke (min−1) | NI | 3.86 × 10−2 | 50 | NI | 4.60 × 10−2 | 32 | ||||
| σG | N/A | 0.137 | 37 | N/A | 5.02 × 10−2† | 62 | ||||
| σI | N/A | 0.433 | 55 | N/A | 0.146* | 26 | ||||