Parameter | ACV | VACV | GVACV | VVACV | VYACV |
---|---|---|---|---|---|
AUC(0-last) (TC) (min μg ml−1) | 20.4 ± 3.8 | 237.1 ± 64.6 | 633.8 ± 115.5 | 157.3 ± 74.2 | 225.7 ± 26.4 |
AUCinf (TC) (min μg ml−1) | 29.9 ± 4.2 | 288.6 ± 59.4 | 900.7 ± 74.8 | 258.2 ± 37.5 | 290.9 ± 38.7 |
Cmax (TC) (μg ml−1) | 0.83 ± 0.19 | 5.44 ± 2.33 | 7.2 ± 3.3 | 1.27 ± 0.22 | 1.85 ± 0.31 |
Tmax (TC) (min) | 24.0 ± 5.4 | 20.0 | 22.2 ± 8.3 | 15.0 ± 10.0 | 15.0 ± 10.0 |
Clast (TC) (μg ml−1) | 0.06 ± 0.01 | 0.25 ± 0.01 | 1.1 ± 0.21 | 0.42 ± 0.26 | 0.47 ± 0.06 |
AUC(0-t) (ACV) (min μg ml−1) | 20.47 ± 3.8 | 232.53 ± 66.04 | 571.68 ± 99.22 | 96.8 ± 24.4 | 226.72 ± 26.72 |
AUC(0-t) (AA) (min μg ml−1) | 15.02 ± 0.48 | 133.1 ± 48.2 | 95.8 ± 1.1 | ||
Cmax (ACV) (μg ml−1) | 0.83 ± 0.19 | 5.30 ± 2.38 | 6.9 ± 1.50 | 0.82 ± 0.39 | 1.85 ± 0.31 |
Cmax (AA) (μg ml−1) | 1.08 ± 0.01 | 1.30 ± 0.89 | 0.45 ± 0.01 | ||
Cl/F (ACV) (ml min−1) | 150.5 ± 12.6 | 15.5 ± 3.1 | 13.3 ± 3.5 | 13.9 ± 1.36 | 7.5 ± 0.7 |
Cl/F (AA) (ml min−1) | 26.8 ± 4.5 | 12.2 ± 2.6 | |||
MRT(ACV) (min) | 45.82 ± 5.31 | 60.36 ± 8.76 | 79.61 ± 10.64 | 50.98 ± 18.21 | 102.4 ± 5.02 |
λZ (ACV) (min−1) | 0.017 ± 0.007 | 0.0052 ± 0.001 | 0.006 ± 0.001 | 0.009 ± 0.001 | 0.0072 ± 0.003 |
MRT(AA) (min) | 12.8 ± 0.16 | 73.2 ± 28.9 | 126.1 ± 3.21 | ||
λZ (AA) (min−1) |
|
| 0.006 ± 0.002 | 0.005 ± 0.001 |
|
AA, amino acid intermediate; Cmax (AA) peak concentration of amino acid intermediate; Cmax (ACV) peak concentration of ACV; MRTAA (min), mean residence time of amino acid intermediate; MRTACV (min), mean residence time of ACV; TC, total concentration in terms of ACV.