TABLE 1

Subject characteristics and weight-normalized global indocyanine green and antipyrine pharmacokinetic parameters (n = 5)

Values are mean ± S.D. VSS, the sum of all compartmental volumes, is the volume of distribution at steady-state; CLE is the elimination clearance.

Treatment
Age
Weight
Heart Rate
Mean Arterial Pressure
Cardiac Outputa
Systemic Vascular Resistanceb
Indocyanine Green
Antipyrine
VSS
 CLE
VSS
 CLE
yr kg BPM mm Hg l/min dyn · s · cm -5 ml/kg ml/min/kg ml/kg ml/min/kg
Control 35 ± 9 80 ± 15 53 ± 11 94 ± 11 9.8 ± 2.7 796 ± 163 72 ± 11 16 ± 2 605 ± 155 0.72 ± 0.36
Propranolol
35 ± 9
80 ± 15
49 ± 7
97 ± 8
4.3 ± 0.9*
1853 ± 491*
64 ± 7
12 ± 4*
587 ± 35
0.57 ± 0.18

  • BPM, beats per minute.

  • ↵ a Determined by dye (indocyanine green) dilution at the moment of marker injection.

  • ↵ b Mean central venous pressure assumed to be zero.

  • ↵* Significantly different from control, p < 0.05.