Biochemical parameters in the long-term (32-week) experimental model
Data are mean ± S.E.M.
32-Week Study | Control | Diabetes | Diabetes + AG |
|---|---|---|---|
| Body weight (g) | 710 ± 24 | 538 ± 17* | 458 ± 15*# |
| Renal weight (g/m2) | 52 ± 1 | 88 ± 3* | 83 ± 4* |
| Plasma glucose (mmol/l) | 6.3 ± 0.2 | 28.2 ± 1.5* | 28.0 ± 1.5* |
| Glycated Hb (%) | 4.2 ± 0.2 | 15.3 ± 0.8* | 14.0 ± 0.6* |
| AER (mg/day) | 4.2 ×/÷ 1.3 | 52 ×/+ 1.3* | 4.2 ×/+ 1.3# |
| GFR (ml/min/m2) | 122 ± 4 | 227 ± 9* | 226 ± 16* |
| ERPF (ml/min/m2) | 410 ± 25 | 576 ± 18* | 560 ± 12* |
| LMW AGEs (AU/ml) | 14.8 ± 1.0 | 23.6 ± 1.9 | 15.9 ± 0.8*# |
| Renal AGE fluorescence | 2.0 ± 0.2 | 4.6 ± 0.9* | 2.2 ± 0.3*# |
AG, aminoguanidine.
↵* versus control, p < 0.05; # versus diabetes, p < 0.05.