Pharmacokinetic parameters of Y-700, the unchanged drug, in normal rats
Data are shown as mean ± S.D. (n = 5).
Parameter | Administration Route and Dose of Y-700 | ||||||
|---|---|---|---|---|---|---|---|
| Oral (0.3 mg/kg) | Oral (1 mg/kg) | Oral (3 mg/kg) | Intravenous (1 mg/kg) | ||||
| tmax (h) | 0.5 ± 0.3 | 0.3 ± 0.1 | 0.5 ± 0.3 | — | |||
| Cmax (μg/ml) | 0.43 ± 0.05 | 1.80 ± 0.41 | 6.49 ± 2.25 | 3.97 ± 0.39* | |||
| AUC0—∞ (μg/h/ml) | 2.07 ± 0.13 | 7.01 ± 0.97 | 30.31 ± 2.62 | 8.34 ± 0.59 | |||
| t1/2 (h) | 5.0 ± 1.0 | 3.2 ± 0.4 | 2.7 ± 0.2 | 2.5 ± 0.3 | |||
—, not examined.
↵* C5 min value.