Characteristics of liver samples expressing novel CYP2B6 variants
Variants (N) | Genotype | CYP2B6 Apoprotein | Bupropion Hydroxylase Activity |
|---|---|---|---|
| CYP2B6.1 (28) wild type | *1/*1 | 22.5 ± 16.1 | 262 ± 295 |
| Q21L, R22C (1) | *1/*10 | 6.98 | 46.5 |
| Q21L, R22C, R487C (1) | *5/*10 | 14.62 | 280 |
| R22C, M46V (1) | *2/*11 | 21.1 | 79.5 |
| M46V, R487C (1) | *5/*11 | 18.1 | 182.4 |
| R22C, G99E (1) | *2/*12 | 1.55 | 49.5 |
| K139E, Q172H, K262R (1) | *1/*13 | 19.05 | 136.2 |
| K139E, 172HH, 262RR (2) | *6/*13 | 1.45, 10.61 | 29.5, 23.7 |
| R22C, R140Q, Q172H, K262R (1) | *14/N.D. | 12.63 | 39.4 |
| I391N (3) | *1/*15 | 3.9 ± 0.6 | 47.4 ± 2.3 |
N.D., genotype not unequivocally definable.