TABLE 2

Uptake clearance of reference compounds (E-sul and CCK-8) and test compounds (pitavastatin and E217βG) in human hepatocytes


Substrate

Uptake Clearance (CLhep)a
Lot. OCF
Lot. 094
Lot. ETR
μl/min/106 cells
E-sul 110 134 57.7
CCK-8 7.89 3.50 2.02
pitavastatin 61.3 113 39.2
E217βG
13.5
17.0
5.5
  • a Uptake clearance was determined using three independent batches of human cryopreserved hepatocytes.