Effects of GS39783, baclofen, and chlordiazepoxide on motor performance in the rotarod and traction test Effects of GS39783 (0, 1, 3, 10, and 30 mg/kg p.o.), l-baclofen (2.5–5 mg/kg), and chlordiazepoxide (10 mg/kg p.o.) on rotarod endurance traction and core body temperature in mice. Values represent mean and S.E.M. n = 10 per treatment group.
Drug | Rotarod Endurance | Traction Test |
|---|---|---|
| s | % Successful | |
| Vehicle | 300 + 0 | 100 + 0 |
| GS39763 | ||
| 0.1 mg/kg | 300 + 0 | |
| 1 mg/kg | 300 + 0 | 100 + 0 |
| 10 mg/kg | 300 + 0 | 100 + 0 |
| 50 mg/kg | 300 + 0 | 100 + 0 |
| 100 mg/kg | 300 + 0 | 100 + 0 |
| 200 mg/kg | 231 + 37 | 100 + 0 |
| Baclofen | ||
| 2.5 mg/kg | 214 + 38 | 50* |
| 5 mg/kg | 171 + 43* | 30** |
| Chlordiazepoxide | ||
| 5 mg/kg | 208 + 34 | 100 + 0 |
| 10 mg/kg | 236 + 33 | 100 + 0 |