Curve fit parameters for ligand-stimulated formation of ERCs in HEK-293 cells expressing 5-HT2C-GFP n is the number of independent experiments used to determine the mean ± S.E.M.
Function | Compound | EC50 ± S.E.M. | Emax ± S.E.M. | n |
|---|---|---|---|---|
| nM | % | |||
| Agonist | 5-HT | 81 ± 29 | 100 | 7 |
| Ro 60-0175 | 61 ± 20 | 105 ± 5 | 6 | |
| WAY-161503 | 66 ± 12 | 134 ± 30 | 6 | |
| mCPP | 300 ± 186 | 72 ± 14 | 4 | |
| DOI | 201 ± 167 | 58 ± 10 | 4 | |
| Inverse agonist | SB-206553 | Inactive | Not applicable | 4 |
| Mianserin | Inactive | Not applicable | 4 | |
| Neutral antagonist | SB-242084 | Inactive | Not applicable | 4 |
|
| 5-Methoxygramine | Inactive | Not applicable | 4 |