In vitro MAO-A and MAO-B inhibition by SL25.1131 and various MAO inhibitors in rat brain homogenates
The confidence intervals are shown in parentheses.
Compounds | IC50 | B/A | ||
|---|---|---|---|---|
| MAO-A | MAO-B | |||
| nM | ||||
| SL25.1131 | 6.7 (6.0-7.9) | 16.8 (14.9-18.9) | 2.5 | |
| Befloxatone* | 3.8 (3.6-4.1) | 300 (275-361) | 79 | |
| Cimoxatone* | 2.7 (2.6-2.9) | 90 (83-99) | 33 | |
| Harmaline* | 12 (10-14) | >1000 | >83 | |
| Moclobemide* | 23,000 (21,000-26,000) | >10,000 | >0.5 | |
| Brofaromine* | 15 (14-16) | >1000 | >67 | |
| BW1370U87* | 50 (46-54) | >1000 | >20 | |
| Toloxatone* | 3260 (2860-3660) | 39,000 (31,000-50,500) | >12 | |
| l-Deprenyl* | 970 (864-1000) | 4.6 (3.9-5.5) | <0.005 | |
| Lazabemide* | >10,000 | 30 (25-39) | <0.003 | |