Peptide No. | Peptide Structure | Ki | ||||
---|---|---|---|---|---|---|
hBRS-3/Balb/c 3T3 Cells | hGRP-R/Balb/c 3T3 Cells | hNMB-R/Balb/c 3T3 Cells | ||||
nM | ||||||
1 | [d-Tyr6,β-Ala11,Phe13,Nle14]Bn(6-14) | 0.82 ± 0.1 | 0.5 ± 0.04 | 5.9 ± 0.4 | ||
2 | [d-Tyr6,(R)-Apa11,Phe13,Nle14]Bn(6-14) | 2.8 ± 0.1 | 151 ± 6 | 2400 ± 96 | ||
3 | [d-Tyr6,(S)-Apa11,Phe13,Nle14]Bn(6-14) | 8.2 ± 1.1 | 110 ± 5 | 4370 ± 150 | ||
4 | [d-Tyr6,(S)-Apa11-2Cl,Phe13,Nle14]Bn(6-14) | 85 ± 7 | 398 ± 28 | 5890 ± 385 | ||
5 | [d-Tyr6,(R)-Apa11-2Cl,Phe13,Nle14]Bn(6-14) | 24 ± 1 | 229 ± 28 | 6920 ± 350 | ||
6 | [d-Tyr6,(S)-Apa11-4Cl,Phe13,Nle14]Bn(6-14) | 776 ± 134 | 741 ± 85 | 1950 ± 337 | ||
7 | [d-Tyr6,(R)-Apa11-4Cl,Phe13,Nle14]Bn(6-14) | 8.2 ± 1.1 | 1860 ± 69 | 7200 ± 840 | ||
8 | [d-Tyr6,(S)-Apa11-3Cl,Phe13,Nle14]Bn(6-14) | 15.8 ± 1.1 | 110 ± 17 | 831 ± 192 | ||
9 | [d-Tyr6,(R)-Apa11-3Cl,Phe13,Nle14]Bn(6-14) | 107 ± 4 | 2510 ± 290 | > 10,000 | ||
10 | [d-Tyr6,β-Asp11,Phe13,Nle14]Bn(6-14) | 490 ± 50 | 396 ± 44 | 427 ± 54 | ||
11 | [d-Tyr6,β-Asp(BzlAmd)11,Phe13,Nle14]Bn(6-14) | 708 ± 61 | 397 ± 51 | 646 ± 59 | ||
12 | [d-Tyr6,β-Dap11,Phe13,Nle14]Bn(6-14) | 2.3 ± 0.1 | 1.0 ± 0.1 | 43 ± 5 | ||
13 | [d-Tyr6,Nα-acetyl-Dap11,Phe13,Nle14]Bn(6-14) | 15.8 ± 2.9 | 1.7 ± 0.2 | 89 ± 4 | ||
14 | [d-Tyr6,Nα-benzoyl-Dap11,Phe13,Nle14]Bn(6-14) | 12.3 ± 1.3 | 3.1 ± 0.5 | 55 ± 3 | ||
15 | [d-Tyr6,β-Ala11,Phe13,β-Dap(Pr)14]Bn(6-14) | 2400 ± 138 | 85 ± 17 | > 10,000 | ||
Bn | Bombesin | > 10,000 | 0.36 ± 0.07 | 22 ± 0.9 | ||
NMB | Neuromedin B | > 10,000 | 97 ± 11 | 0.55 ± 0.03 |