TABLE 4

Dopamine and its metabolites contents at 1 h following drug administration

These drugs affected the DA and its metabolite contents at 1 h after dosing in normal mice; however, FR261529 even at a neuroprotective dose in mouse METH model did not modify striatal DA and its metabolites DOPAC, HVA, and 3-MT levels, compared with vehicle-treated mice. In the nontreated control group, the concentrations of DA and its metabolites DOPAC, HVA, and 3-MT were 14.17 ± 0.39, 0.84 ± 0.02, 1.40 ± 0.03, and 0.25 ± 0.02, respectively. Data are presented as mean ± S.E.M. of 5 to 6 mice.

Drug		Route	DA	DOPAC	HVA	3-MT
	mg/kg
METH			106.1 ± 5.6	42.8 ± 1.4^**	156.5 ± 9.1^**	361.5 ± 21.6^**
FR261529	32	p.o.	96.1 ± 3.9	95.8 ± 7.8	104.3 ± 3.8	98.8 ± 3.2
Nomifensine	3.2	i.p.	95.8 ± 4.2	54.2 ± 2.2^**	77.5 ± 2.2^**	94.2 ± 6.6
Haloperidol	3.2	i.p.	50.9 ± 2.1^**	386.3 ± 18.1^**	209.5 ± 9.4^**	53.6 ± 5.1^**
Apomorphine	3.2	i.p.	98.7 ± 1.8	62.9 ± 5.4^**	49.2 ± 4.6^**	67.8 ± 3.1^**

^** Values different from the nontreatment control group (P < 0.01). ^**P < 0.01, significant difference from control value (by Student's t test).