Binding affinities (Ki values; nM) for DiPOA at the human opioid receptors
Ki values represent the mean ± S.E.M. Values in parentheses represent the number of independent determinations used in the calculation of each Ki value.
Compound | Mu | Kappa | Delta | ORL-1 |
|---|---|---|---|---|
| DiPOA | 0.76 ± 0.15 (7) | 243 ± 74 (5) | >10,000 (2) | 286 ± 40 (3) |
| Morphine | 2.06 ± 0.48 (5) | 134 ± 22 (4) | >10,000 (2) | >10,000 (3) |
| Naltrexone | 2.39 ± 0.6 (3) | ND | ND | ND |
| U69,593 | ND | 3.69 ± 0.79 (3) | ND | ND |
| Naloxone | ND | ND | 488 ± 107 (4) | ND |
| Nociceptin | ND | ND | ND | 0.18 ± 0.04 (6) |
ND, not determined.