TABLE 3

Hepatic portal pharmacokinetic parameters of GF120918A after oral administration

Data provided as mean ± S.D.

Portal Cmax
Corrected Portal DNAUC
Hepatic Extractiona
Absorptionb
ng/ml min · kg/l %
Rat, 3 mg/kg suspension 62.4 ± 15.5 4.19 ± 1.02 57.0 ± 2.1 8.87 ± 2.16
Rat, 30 mg/kg suspension 346 ± 84 2.24 ± 1.29 40.5 ± 8.5 5.16 ± 2.39
Dog, 3 mg/kg suspension 416 ± 121 10.1 ± 4.3 24.1 ± 9.3 12.6 ± 5.3
Dog, 30 mg/kg suspension 512 ± 150 1.96 ± 1.24 23.4 ± 17.9 2.44 ± 1.54
Monkey, 3 mg/kg suspension 532 ± 226 42.0 ± 7.1 76.2 ± 3.5 81.4 ± 13.8
Monkey, 30 mg/kg suspension
985 ± 315
19.8 ± 3.3
76.4 ± 3.9
38.3 ± 6.4

  • ↵ a First-pass hepatic extraction estimated from the portal-systemic concentration difference using the method of Ward et al. (2001b).

  • ↵ b Absorption estimated based on the theoretical maximum DNAUC approach of Ward et al. (2001b).