IC50 values for CGS-19755, EAA-090, EAB-318, and MK-801 at inhibiting CPP and PCP binding in rat brain membrane preparations
MK-801 (at 100 μM) showed no inhibition of CPP binding. Percentage of inhibition of AMPA, kainate, and glycine binding with each drug (at 100 μM) are shown.
NMDA | PCP | AMPA | Kainate | Glycine | |
|---|---|---|---|---|---|
| nM | % | ||||
| CGS-19755 | 55 | 22 μM | 11 | 0 | 45 |
| EAA-090 | 28 | 7.5 μM | 17 | 6 | 33 |
| EAB-318 | 7.9 | 719 nM | 43 | 22 | 48 |
| MK-801 | 0% | 9 nM | 8 | 7 | 3 |