TABLE 2

Quantitation of hepatic CYP1A2 mRNA levels

The Northern blots, obtained from experiments described in the legend to Fig. 4, were subjected to phosphor imaging analyses, and the CYP1A12 mRNA levels were estimated in individual animals. Data represent means ± S.E. data from at least three individual animals.

Genotype
Hyperoxia
Pixel Density × 10-3
h
AHR (+/+) 0 21.0 ± 0.82
AHR (+/+) 24 25.0 ± 2.3
AHR (+/+) 48 72.0 ± 9.3a
AHR (+/+) 72 33.0 ± 4.2a
AHR (-/-) 0 7.7 ± 0.18b
AHR (-/-) 24 37.0 ± 4.2a
AHR (-/-) 48 52.0 ± 6.7a
AHR (-/-)
72
6.7 ± 3.2

  • ↵ a Different from air-breathing controls at P < 0.05.

  • ↵ b Different from wild-type air-breathers at P < 0.05.