TABLE 4

Influence of NCX-911 (NO-sildenafil) and sildenafil on LPS-induced changes in bronchoalveolar lavage cell composition BALB/c mice were exposed for 30 min to an aerosol either of NCX-911 (100 μM) or sildenafil (100 μM). After 15 min of resting time, mice were exposed for 30 min to an aerosol of LPS (100 μg/ml) in saline solution or to an aerosol of the saline solution alone (negative control group). Results are expressed in 104 ± S.E.M.

Dose
n
Treatment LPS
Total Cells
Macrophages
Neutrophils
μM
Vehicle 16 – 8.05 ± 1.03 7.89 ± 1.01 1.63 ± 0.03
19 + 64.5 ± 5.5*** 11.81 ± 1.43* 52.40 ± 4.71***
NCX 911 100 6 – 5.15 ± 1.16 5.11 ± 1.15 0.04 ± 0.02
100 7 + 51.48 ± 5.28a 13.12 ± 2.33 35.53 ± 4.10a
Sildenafil 100 5 – 10.81 ± 1.59 10.70 ± 1.57 1.06 ± 0.04
100
16
+
54.61 ± 10.38
11.06 ± 1.46
42.86 ± 9.26

  • n, number of mice.

  • ↵* P < 0.05

  • ↵*** P < 0.001 in comparison with nontreated control mice exposed to saline solution alone

  • ↵ a P < 0.05 in comparison with nontreated control mice exposed to LPS aerosol