ECG analysis of anesthetized neonatal Kcnq1+/+ (WT) and Kcnq1–/– (KO) mice ECG parameters were compared by two-sample Student's t test, and p values are tabulated. Data are mean ± S.E.M.
Parameters | WT (n = 28) | KO (n = 22) | p Value |
|---|---|---|---|
| RR (ms) | 131 ± 4 | 127 ± 3 | 0.49 |
| PR (ms) | 45 ± 1 | 46 ± 2 | 0.73 |
| P-wave amplitude (mV) | 0.34 ± 0.01 | 0.32 ± 0.02 | 0.38 |
| P-wave area (mV·ms·10-1) | 15 ± 0.7 | 15 ± 0.9 | 0.92 |
| QRS duration (ms) | 6.8 ± 0.2 | 7.2 ± 0.2 | 0.18 |
| QRS amplitude (mV) | 1.5 ± 0.1 | 1.6 ± 0.1 | 0.27 |
| JT (ms) | 49 ± 2 | 57 ± 3 | 0.02 |
| QT (ms) | 55 ± 2 | 65 ± 3 | 0.008 |
| QTc (ms) | 49 ± 1 | 57 ± 2 | 0.003 |
| T-wave area (mV·ms·10-1) | 62 ± 3 | 83 ± 7 | 0.008 |