SQV | SQV + GF | SQV + MDZ | SQV + CsA | |
---|---|---|---|---|
Tmax (min) | 9.00 ± 2.92 | 17.5 ± 2.5 | 5.33 ± 2.33 | 70.0 ± 55.8 |
Cmax (ng/ml) | 218 ± 67 | 220 ± 25 | 141 ± 57 | 260 ± 62 |
ka* (min) | 0.184 ± 0.040 | 0.0730 ± 0.0028 | 2.59 ± 1.30 | 0.158 ± 0.044 |
AUC0-t (ng·h/ml) | 134 ± 57 | 126 ± 24 | 227 ± 160 | 729 ± 501 |
AUC0-∞ (ng·h/ml) | 143 ± 62 | 150 ± 46 | 360 ± 282 | 2000 ± 1710 |
t1/2 (h) | 1.83 ± 0.69 | 3.42 ± 3.01 | 4.25 ± 1.72 | 4.73 ± 2.35 |
F I | 0.0809 ± 0.0202 | |||
Fr(I) | 1 | 1.05 ± 0.32 | 2.52 ± 1.97 | 5.36 ± 3.37 |
Fr(I) = (Relative intestinal availability) = PV AUCSQ - inhibitor/PV AUCSQ.
↵* p < 0.05 between groups