1 mg/kg (SA) | 1 mg/kg (PV) | 3 mg/kg (SA) | 5 mg/kg (SA) | |
---|---|---|---|---|
C0 (ng/ml) | 2013 ± 990 | 798 ± 277 | 12,100 ± 6020 | 40,300 ± 9420 |
AUC0-t (ng·h/ml) | 369 ± 73 | 244 ± 74 | 831 ± 80 | 1730 ± 250 |
AUC0-∞ (ng·h/ml) | 432 ± 91 | 273 ± 82 | 913 ± 62 | 1780 ± 260 |
CL/F (l/h/kg) | 2.73 ± 0.68 | n/a | 3.32 ± 0.22 | 2.96 ± 0.50 |
Vz/F (l/kg) | 12.2 ± 4.0 | n/a | 13.0 ± 3.0 | 8.54 ± 0.95 |
Vss (l/kg) | 5.70 ± 1.00 | n/a | 6.04 ± 1.86 | 1.91 ± 0.34 |
ke (h-1) | 0.258 ± 0.054 | 0.306 ± 0.048 | 0.276 ± 0.042 | 0.354 ± 0.062 |
t1/2 (h) | 2.94 ± 0.42 | 2.48 ± 0.46 | 2.67 ± 0.47 | 2.10 ± 0.41 |
Mean residence time (h) | 2.34 ± 0.53 | 2.26 ± 0.13 | 1.77 ± 0.49 | 0.655 ± 0.105 |
n/a, not applicable.