Effects of signal transduction inhibitors on isoproterenol-induced extracellular cAMP (picomoles per milligram of protein) Values are means ± S.E.M. with number of observations in parentheses.
Basal | Isoproterenol | P Value for Effect of Isoproterenol | P Value for Effect of Inhibitor on Effect of Isoproterenol | |
|---|---|---|---|---|
| Fisher's LSD | ANOVA | |||
| Control | 0.872 ± 0.226 (20) | 25.244 ± 1.661 (20) | Significant | |
| HA1077 | 1.378 ± 0.234 (6) | 22.598 ± 2.873 (6) | Significant | 0.3654 |
| Y27632 | 3.811 ± 2.075 (13) | 31.929 ± 3.976 (14) | Significant | 0.3833 |
| LY294002 | 0.799 ± 0.601 (8) | 21.219 ± 2.418 (8) | Significant | 0.2062 |
| Dipenylene-Iodonium | 0.531 ± 0.372 (8) | 30.966 ± 6.245 (8) | Significant | 0.2013 |
| Tempol | 0.395 ± 0.345 (8) | 28.882 ± 6.127 (8) | Significant | 0.3775 |