TABLE 1

Summary of the pharmacology, potency, and source of inhibitors

	Pharmacology	Approximate Potency^a	Source
U73122	Phospholipase C inhibitor	IC₅₀ = 1.0–2.1^b	Tocris Cookson Inc., Ellisville, MO
GF109203X	Protein kinase C	IC₅₀ = 0.0084–5.8^b	Tocris Cookson Inc.
1-Butanol	Phospholipase D inhibitor	IC₅₀ = 10,000	Sigma-Aldrich
CGP77675	c-Src inhibitor	IC₅₀ = 0.04	Novartis, Basel, Switzerland
HA1077	Rho kinase inhibitor	K_i = 0.4	Calbiochem, San Diego, CA
Y27632	Rho kinase inhibitor	K_i = 0.14	Tocris Cookson Inc.
LY294002	Phosphatidylinositol-3-kinase inhibitor	IC₅₀ = 1.4	Tocris Cookson Inc.
Dipenylene-iodonium	NADPH oxidase inhibitor	IC₅₀ = 0.3	Sigma-Aldrich
Tempol	Superoxide dismutase mimetic	EC₅₀ = 54–436^c	Sigma-Aldrich
C₂-Ceramide	Phospholipase D inhibitor	IC₅₀ = 5	Tocris Cookson Inc.
PP1	Src inhibitor	IC₅₀ = 0.005–0.17^b	Tocris Cookson Inc.