TABLE 1

Kinase selectivity profile of AS601245


Inhibition of Isolated Enzyme Activity

AS601245
IC50 in mM
JNK1 0.15
JNK2 0.22
JNK3 0.07
p38a >10
ERK1 >10
MEK1 >10
PKC >10
AKT >10
p56Lck >10
EGF
>10
  • EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; MEK, mitogen-activated protein kinase kinase; PKC, protein kinase C.