TABLE 3

Body weight and relative weight of the liver and adipose tissue in KK-Ay mice treated with NS-220 or fenofibrate for 14 days Each group of five KK-Ay mice was orally administered NS-220 or fenofibrate once daily for 14 days. The body, the excised liver, and the excised adipose tissue were weighed the day after the last administration. Liver and adipose tissue weight is shown relative to 100 g of body weight.

Drug
Dose
Body
Livera
Adipose Tissue
mg/kg g g%
Control 41.7 ± 0.5 5.70 ± 0.16 3.59 ± 0.17
NS-220 0.1 42.3 ± 0.9 6.30 ± 0.08b 3.55 ± 0.14
0.3 44.0 ± 0.8 8.02 ± 0.12c 3.31 ± 0.14
1 43.9 ± 1.0 11.52 ± 0.25c 2.95 ± 0.08c
Fenofibrate
100
43.2 ± 1.1
8.72 ± 0.18c
3.25 ± 0.11

  • ↵ a g/100 g of body weight

  • ↵ b Significantly different from control at P < 0.05 (Dunnett's test)

  • ↵ c Significantly different from control at P < 0.01 (Dunnett's test)