Summary of OSI-7904L dose schedule comparison of tumor response to 5-FU and OSI-7904
Treatment | TGI | Regression Day 22 | LCK | Cures | |
|---|---|---|---|---|---|
| % | |||||
| Control | 0 | 0 | 0 | 0 | |
| OSI-7904L; 25 mg/kg, q.d. 1, 8 | 97 | 88 | 4.2 | 1 | |
| OSI-7904L; 15 mg/kg, q.d. 1, 3, 5 × 2 | 95 | 86 | 3.2 | 1 | |
| OSI-7904L; 7.5 mg/kg, q.d. 1-5 × 2 | 96 | 88 | 3.9 | 1 | |
| OSI-7904; 100 mg/kg, q.d. 1-5 × 2 | 80 | 0 | 2.4 | 0 | |
| 5-FU; 100 mg/kg, q.d. 1, 8 | 72 | 0 | 1.5 | 0 | |
q.d. 1, 8, study days 1 and 8; q.d. 1, 3, 5, study days 1, 3, and 5; q.d. 1-5 × 2, study days 1-5 and 8-12.