TABLE 3
Dose-normalized pharmacokinetic parameters for tumor tissue
Formulation
HT-29
HCT-8 TK-/-
AUC
0→∞
C
max
AUC
0→∞
C
max
μ
g·h/g
μ
g/g
μ
g·h/g
μ
g/g
OSI-7904L
281
13.9
397
10.7
OSI-7904
2.52
6.98
3.71
2.24