TABLE 1

Three-dimensional transporter structures

Protein	Organism	Transmembrane domains					Other Domains	Structure Determination			Reference
Protein	Organism			Number	TMH (Segments)/Domain	TMH (Segments)/Transporter	Other Domains		Method^a	Resolution	Reference
NhaA	E. coli	1	12	12		ECM	7-14 Å	Williams, 2000
OxlT	O. formigenes	1	12	12		ECM	6.5 Å	Hirai et al., 2002
EmrE	E. coli	2	4	8		ECM	7 Å	Ubarretxena-Belandia et al., 2003
MDR1 P-gp	Chinese hamster ovary cells	2	6	12	2 NBD	ECM	10 Å	Rosenberg et al., 2001
MDR3 P-gp	Mouse MDR3 P-gp expressed in Pichia pastoris	2				ECM	22 Å	Lee et al., 2002
Multidrug efflux transporter, Pdr5p	S. cerevisiae	2			2 “stalk” formed, 2 NBD	ECM	25 Å	Ferreira-Pereira et al., 2003
Multidrug transporter, YvcC	Bacillus subtilus YvcC expressed in E. coli	2			2 “stalk” formed, 2 NBD	ECM	25 Å	Chami et al., 2002
LacY	E. coli	2	6	12		X-ray	3.5 Å	Abramson et al., 2003
GlpT	E. coli	2	6	12		X-ray	3.3 Å	Huang et al., 2003
Multidrug efflux	E. coli	3	12	36	3 AcrA, 3 TolC	X-ray	3.5 Å	Murakami et al., 2002
transporter, AcrB							3.7 Å (with ligands)	Yu et al., 2003
Lipid flippase, MsbA	E. coli	2	6	12	2 NBD	X-ray	4.5 Å	Chang and Roth, 2001
Vitamin B₁₂ transporter, BtuCD	E. coli	2 (BtuC)	10	20	2 NBD (BtuD)	X-ray	3.2 Å	Locher et al., 2002
Calcium ATPase, SERCA1a	Skeletal muscle sarcoplasmic reticulum	1	10	10	1 NBD, 1 P-site	X-ray	2.6 Å (with Ca²⁺)	Toyoshima et al., 2000
							3.1 Å	Toyoshima and Nomura, 2002