TABLE 1

Pharmacokinetic parameters of intravenous 2OHE and 2MEOE in male rats

Parameter
Unit
2OHE
2MEOE
2MEOE
Drug Infused NA 2OHE 2OHE 2MEOE
Dose mg/kg 0.5 0.5 0.5
AUC ng·ml−1·min 411 10,182 10,066
CL ml·min−1·kg−1 1,215 49.1 49.7
Cmax ng/ml 107 494 584
Co ng/ml 216 495 751
Vc ml/kg 2,315 1,010 666
t ½ (1) min 0.94 7.9 2.5
t ½ (2) min 10.2 24.9 20.2
Vd
ml/kg
17,875
1,760
1,500

  • CL, intravenous clearance based on AUC from zero to last measurable time point; NA, not applicable.