TABLE 2

Correlation between DA content and DAT binding site in the striatum after MPTP treatment in mice MPTP (20 mg/kg) was injected intraperitoneally four times at 2-h intervals, and dopamine content and DAT binding site in the striatum were measured after 24 and 96 h. Both dopamine content and DAT binding site were significantly decreased by MPTP treatment after 24 h, with marked reduction after 96 h. Decrease of dopamine content level was coincident with that of DAT binding site. Values are means ± S.E.M. of n = 5 to 6 mice.