TABLE 1

Selectivity profile of GLU_K5 ligands Functional and receptor binding assays were performed as described under Materials and Methods. Results are means ± S.E.M. from at least three separate determinations.

Compound	GLU_K5 IC₅₀^a	GLU_K6 IC₅₀^a	[³H]ATPA K_i^b	[³H]Kainate K_i^b
	μM
ATPA	0.21 ± 0.03	>300	0.0094 ± 0.0010	>100
NS1209	0.63 ± 0.09	65 ± 4	0.62 ± 0.11	13 ± 4.0
NS3763	1.6 ± 0.2	>30	>30	>30

↵ a Functional selectivity at recombinant homomeric GLU_K5 and homomeric GLU_K6 receptors expressed in HEK293 cells, determined by measurements of intracellular calcium. IC₅₀ values were calculated from percentage of inhibition of domoate-induced calcium influx
↵ b Selectivity in ligand binding assays to homomeric GLU_K5 and homomeric GLU_K6 receptors expressed in HEK293 cells. K_i values for NS1209 are from Varming et al. (2001)