Pharmacology of sumatriptan in saphenous vein and basilar artery, with and without endothelium
Data are mean values with standard error of means from three to five independent experiments.
Tissue | Endothelium | l-NAME | pEC50 | Emax (% KCl) | Hill Slope |
|---|---|---|---|---|---|
| Saphenous vein | + | − | 4.92 ± 0.36 | 33.6 ± 9.7 | 0.94 ± 0.51 |
| Saphenous vein | + | + | 5.76 ± 0.15 | 67.4 ± 6.1 | 1.24 ± 0.49 |
| P<0.05 | P<0.05 | ||||
| Saphenous vein | − | − | 5.70 ± 0.14 | 38.8 ± 3.2 | 0.97 ± 0.28 |
| Saphenous vein | − | + | 6.08 ± 0.15 | 69.2 ± 5.5 | 1.18 ± 0.47 |
| P<0.05 | |||||
| Basilar artery | + | − | N.D. | 10.1 ± 1.2 | N.D. |
| Basilar artery | + | + | 6.44 ± 0.20 | 89.5 ± 8.2 | 1.29 ± 0.72 |
| P<0.05 | |||||
| Basilar artery | − | − | 6.59 ± 0.12 | 57.8 ± 4.7 | 1.52 ± 0.63 |
| Basilar artery | − | + | 6.49 ± 0.11 | 109.5 ± 8.2 | 1.27 ± 0.42 |
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| P<0.05 |
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N.D., not determined
P < 0.05, statistical significance in a t test.