Parameters | Wistar Rats | SD Rats | EHBRs | ||
---|---|---|---|---|---|
MPA Alone | + Tacrolimus | + Cyclosporin A | MPA Alone | MPA Alone | |
X0 (μg) | 1525 ± 96.8 | 1666.7 ± 72.7 | 1387.5 ± 68.6 | 1825 ± 25.0 | 1863 ± 51.5 |
C0 (μg/ml) | 42.7 ± 0.6 | 39.7 ± 1.4 | 42.3 ± 1.7 | 52.8 ± 2.4* | 41.6 ± 1.0b |
Ke (h-1) | 1.9 ± 0.1 | 2.1 ± 0.0 | 2.0 ± 0.0 | 1.4 ± 0.1** | 2.3 ± 0.2b |
AUCi.v.,0-1 (μg · h/ml) | 22.6 ± 1.3 | 19.4 ± 0.5 | 21.4 ± 0.7 | 38.8 ± 3.0** | 18.7 ± 1.2b |
CLtot (l·h-1) | 0.07 ± 0.00 | 0.09 ± 0.00a | 0.06 ± 0.00 | 0.05 ± 0.00* | 0.10 ± 0.01b |
VD (liters) | 0.04 ± 0.00 | 0.04 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.04 ± 0.00b |