Receptor Subtype | Preparation | Prostamide F2α EC50 | Receptor Selective Prostanoid EC50 (nM) |
---|---|---|---|
DP | Inhibition of ADP-induced human platelet aggregation | NA | PGD2 = 79 |
EP1 | Guinea pig ileum | >10,000 | PGE2 = 6 |
EP3 | Inhibition of field stimulated guinea pig vas deferens | 1585 | Sulprostone = 0.2 |
FP | Relaxation of rabbit jugular vein | 2000 | PGF2α = 2.8 |
CRL 1497 fibroblasts | 1586 | PGF2α = 25 | |
IP | Inhibition of ADP-induced human platelet aggregation | NA | Carbaprostacyclin = 708 |
TP | Rat aorta contraction | >10,000 | U-46619 = 10 |
NA, not active.